when did they stop giving the smallpox vaccine when did they stop giving the smallpox vaccine

One of the deadliest diseases known to humans, smallpox remains the only human disease Through the widespread administration of the smallpox vaccine, doctors declared the smallpox virus "extinct" in the United States in 1952. In December 1979 they concluded that smallpox had been eradicated; a conclusion endorsed by the WHO General Assembly in May 1980. The United States stopped giving mandatory smallpox. Geburtstag von Landesphysikus Gebhard Schaedler. The second-generation vaccines are also administered through scarification with a bifurcated needle, and they carry the same side effects as the first-generation vaccinia strain that was cloned. [104] During 179092 Peter Plett, a teacher from Holstein, reported limited results of cowpox inoculation to the Medical Faculty of the University of Kiel. Thanks to vaccination, smallpox was completely eradicated in 1979. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. At first healthcare workers diagnosed him with malaria, and then chickenpox. Glycerine was sometimes used simply as a diluent by some continental vaccine producers. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. You are a medical researcher working for Pfizer, which has developed a new meningococcal vaccine. If you still get the disease, you might get much less sick than an unvaccinated person would. The World Health Organization maintained a stockpile of 200million doses in 1980, to guard against reemergence of the disease, but 99% of the stockpile was destroyed in the late 1980s when smallpox failed to return. in the most severe forms of disease. The term vaccinia now refers only to the smallpox vaccine,[137] while cowpox no longer has a Latin name. [13] The development of freeze-dried vaccine in the 1950s made it possible to preserve vaccinia virus for long periods of time without refrigeration, leading to the availability of freeze-dried vaccines such as Dryvax. ", "Edward Jenner's unpublished cowpox inquiry and the Royal Society: Everard Home's report to Sir Joseph Banks", "First X, Then Y, Now Z: Landmark Thematic Maps Medicine", "Vaccine Voyages: where science meets slavery", "Zum 200. The vaccine was soon in use on other continents, where vaccine continued to be inoculated from arm to arm until vaccination programmes were established. [15]:127376 These states report that their repositories are for possible anti-bioweaponry research and insurance if some obscure reservoir of natural smallpox is discovered in the future. It took another 50 years to achieve global solidarity in the fight against the disease. These cookies may also be used for advertising purposes by these third parties. Over thousands of years, smallpox killed hundreds of millions of people. [90][91] The first smallpox vaccine in the United States was administered in 1799. [13] However, Sanofi dropped its own vaccine after it acquired Acambis in 2008. They help us to know which pages are the most and least popular and see how visitors move around the site. Mozart was infected, as was Abraham Lincoln. In 1714 and 1716, two reports of the Ottoman Empire Turkish method of inoculation were made to the Royal Society in England, by Emmanuel Timoni, a doctor affiliated with the British Embassy in Constantinople,[69] and Giacomo Pylarini. [97] The vaccine was not carried in the form of flasks, but in the form of 22 orphaned boys, who were 'carriers' of the live cowpox virus. Centers for Disease Control and Prevention. Having heard of local beliefs and practices in rural communities that cowpox It was one of the deadliest diseases known to humans, and to date (2016) the only human disease to have been eradicated by vaccination. [22] The Texas Department of Health began producing egg-based vaccine in 1939 and started using it in vaccination campaigns in 1948. After a successful Phase I trial of ACAM1000, the virus was passaged three times in Vero cells to develop ACAM2000, which entered mass production at Baxter. Traces of smallpox pustules found on the head of the 3000-year-old mummy of the Pharaoh Ramses V. Photo courtesy of World Health Organization (WHO). For example, if you had a prolonged face-to-face contact with someone who has smallpox. However, Fewster, who had a flourishing variolation practice, may have considered this option but used smallpox instead. [76], In the early empirical days of vaccination, before Louis Pasteur's work on establishing the germ theory and Joseph Lister's on antisepsis and asepsis, there was considerable cross-infection. Or treat people with a vaccine that is extremely effective at blocking the disease but can cause dangerous, sometimes fatal, reactions. [18], First generation vaccines consist of live, unattenuated vaccinia virus. Vaccine issued by the Government Vaccine Establishment contained 5,000 bacteria per gram, while commercial vaccines contained up to 100,000 per gram. To stay protected from smallpox, you should get booster vaccinations every 3 years. The basis for vaccination began in 1796 when the English doctor Edward Jenner noticed that milkmaids who had gotten cowpox were protected from smallpox. Saving Lives, Protecting People, Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Community-Based Planning for a Smallpox Emergency, Help People with Functional, Language, or Cognitive Needs, Sample Alert Messages for Healthcare Providers, Comparison of Reactions for First-Time Vaccinees and Revaccinees, Examples of Major or Take Reactions to Smallpox Vaccination, Administering ACAM2000 Smallpox Vaccine Videos, Specimen Collection and Transport Guidelines for Suspect Smallpox Cases, Specimen Collection and Transport Guidelines for Suspect Smallpox Vaccine Adverse Events, Negative Staining Electron Microscope Protocol for Rash Illness, Packaging and Transporting Infectious Substances, Chart 1: Acute, Generalized Vesicular or Pustular Rash Illness Protocol, Chart 2: Laboratory Testing for Acute, Generalized Vesicular or Pustular Rash Illness, Chart 3: Laboratory Testing for Suspect Smallpox Vaccine Adverse Event (Vaccinia), Chart 4: Laboratory Testing for Environmental Sample, U.S. Department of Health & Human Services. In 1978, Parker was a medical photographer at Englands Birmingham University Medical School. ", "Compulsory smallpox vaccination; the University City, Missouri, case", "A Brief Biography of Dr. Louis T. Wright", "Spotlight on Black Inventors, Scientists, and Engineers", "The Milroy Lectures on the Natural History of Vaccina: Delivered at the Royal College of Physicians", "Development of Smallpox Vaccine in England in the Eighteenth and Nineteenth Centuries", "The development of a stable smallpox vaccine", "Development of a stable smallpox vaccine: Collier L. J Hyg 1955; 53: 76101", "US smallpox vaccination plan grinds to a halt", "Third Generation Smallpox Vaccine (6D024-215700/A)", "Canada considering smallpox vaccine for monkeypox cases, says Dr. Theresa Tam", "Statement from the Minister of Health on Canada's Response to Monkeypox", "Incongruencies in Vaccinia Virus Phylogenetic Trees", "Equination (inoculation of horsepox): An early alternative to vaccination (inoculation of cowpox) and the potential role of horsepox virus in the origin of the smallpox vaccine", "The origins and genomic diversity of American Civil War Era smallpox vaccine strains", "Revisiting Jenner's mysteries, the role of the Beaugency lymph in the evolutionary path of ancient smallpox vaccines", "Re-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA", "Early smallpox vaccine manufacturing in the United States: Introduction of the "animal vaccine" in 1870, establishment of "vaccine farms", and the beginnings of the vaccine industry", "Edward Jenner's inquiry after 200 years", "Smallpox/Monkeypox Vaccine Information Statement", "Medication Guide Smallpox (Vaccinia) Vaccine, Live ACAM2000", "Monkeypox Update: FDA Authorizes Emergency Use of Jynneos Vaccine to Increase Vaccine Supply", https://en.wikipedia.org/w/index.php?title=Smallpox_vaccine&oldid=1141059245, This page was last edited on 23 February 2023, at 04:03. [72], Stimulated by a severe epidemic, variolation was first employed in North America in 1721. Although theoretically still compulsory, the 1907 Act effectively marked the end of compulsory infant vaccination in England. [41][42] Clinical trials have found that MVA-BN is safer and just as immunogenic as ACAM2000. Her mother, who was providing care for her, developed smallpox on September 7, despite having been vaccinated two weeks earlier. Some healthcare systems refused to participate, worried about becoming a destination for smallpox patients in the event of an epidemic. She returned to London and had her daughter variolated in 1721 by Charles Maitland, during an epidemic of smallpox. The aim of the current review was to synthesise all 27 studies conducted in . 1520% of children receiving the vaccine for the first time develop fevers of over 102F (39C). The smallpox vaccine is the first vaccine to be developed against a contagious disease. Smallpox can be prevented by smallpox vaccines, also called vaccinia virus vaccines. Jenner also knew about variolation and guessed that exposure to cowpox could be used to protect against smallpox. Working at the Chiba Serum Institute in Japan, So Hashizume passaged the Lister strain 45 times in primary rabbit kidney cells, interrupting the process after passages 36, 42, and 45 to grow clones on chorioallantoic membrane and select for pock size. During variolation, people who had never had smallpox were exposed to material from smallpox sores (pustules) by scratching the material into their arm or inhaling it through the nose. Smallpox was an unknown disease not only in 16th century Mexico, but in all the Americas, before the arrival of Europeans. "[47], In May 2007, the Vaccines and Related Biological Products Advisory Committee (VRBPAC) of the U.S. Food and Drug Administration (FDA) voted unanimously that a new live virus vaccine produced by Acambis, ACAM2000, is both safe and effective for use in persons at high risk of exposure to smallpox virus. The main sign of smallpox is a rash that starts as flat red spots that turn into blisters. Six strains of vaccinia were isolated from 3,000 doses of Dryvax and found to exhibit significant variation in virulence. [15]:588 Lederle Laboratories began selling its Avianized smallpox vaccine in the United States in 1959. [102] The first vaccination was carried out in Liechtenstein in 1801, and from 1812 it was mandatory to vaccinate. First-generation vaccines grown on the skin of live animals were widely distributed in the 1950s1970s to eradicate smallpox. The symptoms of smallpox were gruesome: high fever, vomiting and mouth sores, followed by fluid-filled lesions on the whole body. And thanks to a series of programmes designed to eradicate the disease - which involved identifying all cases and their contacts and ensuring that they were all vaccinated - it was eliminated in the second half of the 20th century. As the World Health Organization launched the Smallpox Eradication Programme in 1959, WHO Member States enhanced their support and cooperation. [79][80], Edward Jenner was born in Berkeley, England as an orphan. [122], A major contribution to smallpox vaccination was made in the 1960s by Benjamin Rubin, an American microbiologist working for Wyeth Laboratories. Some of the earliest statistical and epidemiological studies were performed by James Jurin in 1727 and Daniel Bernoulli in 1766. First-generation vaccines grown on the skin of live animals were widely distributed in the 1950s-1970s to eradicate smallpox. A Cochrane review which explored the factors that influence caregivers' views and practices around routine childhood vaccines worldwide was conducted by Cooper and colleagues. [119][120] Collier added 0.5% phenol to the vaccine to reduce the number of bacterial contaminants but the key stage was to add 5% peptone to the liquid vaccine before it was dispensed into ampoules. Most first-generation vaccines are calf lymph vaccines that were grown on the skin of cows, but other animals were also used, including sheep. In higher-risk countries, laboratories began to produce higher-quality freeze-dried vaccines, and mass production of the innovative and easy-to-use Thanks to the combined efforts of national health agencies, WHO and scientists around the world, smallpox was eliminated from South America in 1971, Asia in 1975 and Africa in 1977. All English stocks held at St Mary's Hospital, London were transferred to more secure facilities at Porton Down and then to the U.S. at the Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia in 1982, and all South African stocks were destroyed in 1983. Bolstered by efforts united around the world, Jenners concept survived to defeat a historic scourge. Two reports on the Chinese practice of inoculation were received by the Royal Society in London in 1700; one by Dr. Martin Lister who received a report by an employee of the East India Company stationed in China and another by Clopton Havers. British, Canadian, Cuban, French, Soviet, and US vaccines were given freely to WHO and distributed onwards, sometimes with the strategic financial support of Sweden. If there is a smallpox outbreak, public health officials will say who else should get the vaccine. On 9 December, 1979, health officials declared smallpox as the first and only human disease to be eradicated in what is considered the greatest achievement of modern medicine. Concern about its safety led to opposition and then repeal of legislation in some instances. [18] Rare side effects include postvaccinal encephalitis and myopericarditis. On October 12, 1977, he rode with two smallpox patients in a vehicle from the hospital to the local smallpox office. After variolation, people usually developed the symptoms associated with smallpox, such as fever and a rash. This caused confusion at the time, but would become important criteria in vaccine development. which came from endemic countries for their own eradication efforts. From 1958 to 1977, the World Health Organization (WHO) conducted a global vaccination campaign that eradicated smallpox, making it the only human disease to be eradicated. Rumours circulated at the time that it would turn people into cows. [88] In the case of arm-to-arm transfer there was also the risk of transmitting syphilis. Ein Liechtensteinischer Artzt als Pionier der Pockenschutzimpfung. It was an unprecedented demonstration of global unity in the face of a common threat. Smallpox vaccine was successfully maintained in cattle starting in the 1840s, and calf lymph vaccine became the leading smallpox vaccine in the 1880s. However, fewer people died from variolation than if they had acquired smallpox naturally. The origin of smallpox is unknown. The horsepox virus was sequenced in 2006 and found to be most closely related to vaccinia. Laboratories in many countries where smallpox occurred regularly were able to produce more, higher-quality freeze-dried vaccine. [105] John Fewster, a surgeon friend of Jenner's from nearby Thornbury, discussed the possibility of cowpox inoculation at meetings as early as 1765. All three generations of vaccine are available in stockpiles. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. [67] According to Voltaire (1742), the Turks derived their use of inoculation from neighbouring Circassia. In 1981, the four countries that either served as a WHO collaborating center or were actively working with variola virus were the United States, England, Russia, and South Africa. [121], Smallpox vaccine was inoculated by scratches into the superficial layers of the skin, with a wide variety of instruments used to achieve this. The patients would then develop a mild case of the disease and from then on were immune to it. In the early part of the 18th century, Boston, a city of 10,000 people, suffered an epidemic of smallpox 5,000 people were infected and 800 died from the disease. [29] During the smallpox eradication campaign, MVA was considered to be a pre-vaccine that would be administered before a replicating vaccine to reduce the side effects, or an alternative vaccine that could be safely given to people at high risk from a replicating vaccine. There is no example of any one that has died in it, and you may believe I am very well satisfied of the safety of the experiment since I intend to try it on my dear little son. There are two licensed smallpox vaccines in the United States and one investigational vaccine that may be used in a smallpox emergency. The technique did have a 0.52.0% mortality rate, but that was considerably less than the 2030% mortality rate of the disease itself. [118] The level of bacterial contamination remained unregulated until the Therapeutic Substances Act, 1925 set an upper limit of 5,000 per gram, and rejected any batch of vaccine found to contain the causative organisms of erysipelas or wound infections. Charles Creighton believed that uncontaminated vaccine itself was a cause of syphilis. From 1796 to the 1880s, the vaccine was transmitted from one person to another through arm-to-arm vaccination. If you still get the disease, you might not get as sick as an unvaccinated person would. At the same time the 1898 Vaccination Act banned arm-to-arm vaccination, thus preventing transmission of syphilis by this vaccine. Airborne spread is thought to be less frequent, but transmission over significant distances has been documented, including transmission through a hospital stairwell. LC16m8 was approved in Japan in 1975 after testing in over 50,000 children. In the latest development to come shortly after Murdoch admitted he did nothing to stop his Fox News talent from "promoting" ex-President . The WHO funded work in the 1960s at the Dutch National Institute for Public Health and the Environment (RVIM) on growing the Lister/Elstree strain in rabbit kidney cells and tested it in 45,443 Indonesian children in 1973, with comparable results to the same strain of calf lymph vaccine. Almost two centuries after Jenner hoped that vaccination could annihilate smallpox, the 33rd World Health Assembly declared the world free of this disease on May 8, 1980. Jenner assumed a causal connection but the idea was not taken up at that time. It was a disease that didnt discriminate, killing at least 1 in 3 people infected, often more in the most severe forms of disease. [123] Those closely involved in the campaign were awarded the "Order of the Bifurcated Needle". The original Ankara strain of vaccinia was maintained at the vaccine institute in Ankara, Turkey on donkeys and cows. [55] Replicating vaccines also remain effective even at 1:10 dilution, so a limited number of doses can be stretched to cover a much larger population. have questioned the possible effectiveness of such a vaccine. 2 But the timing of this decision was by no means inevitable. Within 4 to 7 days of being exposed to the virus, the vaccine likely gives you some protection from the disease. Smallpox was highly infectious, with no known cure. [81] At the age of 13, he was apprenticed to apothecary Daniel Ludlow and later surgeon George Hardwick in nearby Sodbury. Two months later, in July 1796, Jenner took matter from a human smallpox sore and inoculated Phipps with it to test his resistance. Around the same time, it came to public attention in the American colonies. The Program made steady progress toward ridding the world of this disease, and by 1971 smallpox was eradicated from South America, followed by Asia (1975), and finally Africa (1977). The smallpox vaccine is the best protection you can get if you are exposed to the smallpox virus. ACAM2000 is a vaccine developed by Acambis, which was acquired by Sanofi Pasteur in 2008, before selling the smallpox vaccine to Emergent Biosolutions in 2017. While vaccine research continued, new vaccines were not introduced during the 1970s. For this reason, 19th and 20th century researchers developed vaccines against cholera, pertussis, influenza and more by killing the pathogen entirely, either via heat or formalin, a diluted . [74] However, a limited trial showed six deaths occurred out of 244 who were variolated (2.5%), while 844 out of 5980 died of natural disease (14%), and the process was widely adopted throughout the colonies. One of the first methods for controlling smallpox was variolation, a process named after the virus that causes smallpox (variola virus). They make parties for this purpose, and when they are met (commonly fifteen or sixteen together) the old woman comes with a nutshell full of the matter of the best sort of small-pox and asks what veins you please to have opened. However, the use of eggs or cell culture allows for vaccine production in a sterile environment, while first-generation vaccine contains skin bacteria from the animal that the vaccine was grown on. To test his theory, Dr. Jenner took material from a cowpox sore on milkmaid Sarah Nelmes hand and inoculated it into the arm of James Phipps, the 9-year-old son of Jenners gardener. You can review and change the way we collect information below. Publication of the Inquiry and the subsequent energetic promulgation by Jenner of the idea of vaccination with a virus other than variola virus constituted a watershed in the control of smallpox for which he, more than anyone else deserves the credit. The children or young patients play together all the rest of the day and are in perfect health till the eighth. In 1774 Jesty, a farmer of Yetminster in Dorset, observing that the two milkmaids living with his family were immune to smallpox, inoculated his family with cowpox to protect them from smallpox. However, a single-nucleotide deletion truncates membrane protein B5R from a residue length of 317 to 92. Janet Parker was the last person to die of smallpox. [133]:9 Edward Jenner had obtained his vaccine from a cow, so he named the virus vaccinia, after the Latin word for cow. This encouraged the British Royal Family to take an interest and a trial of variolation was carried out on prisoners in Newgate Prison. Allan Watt Downie demonstrated in 1939 that the modern smallpox vaccine was serologically distinct from cowpox,[11] and vaccinia was subsequently recognized as a separate viral species. [109], Louis T. Wright,[110] an African-American Harvard Medical School graduate (1915), introduced, while serving in the Army during World War I, intradermal, smallpox vaccination for the soldiers. While his deputy, Jos Salvany, took vaccine to the west and east coasts of Spanish South America, Balmis sailed to Manila in the Philippines and on to Canton and Macao on the Chinese coast. [43][44][45], LC16m8 is a replicating attenuated strain of vaccinia that is manufactured by Kaketsuken in Japan. In 1959, the World Health Organization (WHO) launched a plan to eradicate the disease by conducting mass immunizations around the world. Rahima was the last known person to have had naturally acquired smallpox in the world. [36], MVA-BN can also be administered intradermally to increase the number of available doses. [71] The success of these variolations assured the British people that the procedure was safe. Three-year-old Rahima Banu with her mother in Bangladesh. This was successful and in 1722 Caroline of Ansbach, the Princess of Wales, allowed Maitland to vaccinate her children. [95][96], In 1804 the Balmis Expedition, an official Spanish mission commanded by Francisco Javier de Balmis, sailed to spread the vaccine throughout the Spanish Empire, first to the Canary Islands and on to Spanish Central America. Compulsory infant vaccination was introduced in England by the 1853. The procedure had been known in Boston since 1706, when preacher Cotton Mather learned it from Onesimus, a man he held as a slave, who like many of his peers had been inoculated in Africa before they were kidnapped. [88] A further source of confusion was Jenner's belief that fully effective vaccine obtained from cows originated in an equine disease, which he mistakenly referred to as grease. Mandatory smallpox vaccination came into effect in Britain and parts of the United States of America in the 1840s and 1850s, as well as in other parts of the world, leading to the establishment of the smallpox vaccination certificates required for travel. On October 22, he developed a fever. 1766", "An examination of John Fewster's role in the discovery of smallpox vaccination", "Who discovered smallpox vaccination? [48], Since smallpox has been eradicated, the public is not routinely vaccinated against the disease. [15]:545,550, In a letter about landmarks in the history of smallpox vaccine, written to and quoted from by Derrick Baxby, Donald Henderson, chief of the Smallpox Eradication Unit from 1967 to 1977 wrote; "Copeman and Collier made an enormous contribution for which neither, in my opinion ever received due credit". According to the US Centers for Disease Control and Prevention (CDC), "within 3 days of being exposed to the virus, the vaccine might protect you from getting the disease. [15], The inoculation technique was documented as having a mortality rate of only one in a thousand. Laboratories in many countries where smallpox occurred regularly were able to produce more, higher-quality freeze-dried vaccine. Good progress was made in many countries with the support of technical assistance and vaccine provision coordinated by WHO. Although now mythological, a review of the events of April 1947, from copies of The New York Times (1,2), tells of a more recognizably human response: pushing, jawing, deceit, shortages, surpluses, and perhaps a . The cost of the Intensified Smallpox Eradication Programme was approximately US$300 million, two thirds of Vaccination led to smallpox elimination in western Europe, North America and Japan. [87] Vaccination, the term which soon replaced cowpox inoculation and vaccine inoculation, was first used in print by Jenner's friend, Richard Dunning in 1800. Jenner had sent the paper informally to Sir Joseph Banks, the Society's president, who asked Everard Home for his views. However, private practitioners had to purchase vaccine from commercial producers. After 23 weeks, the scab will fall off and leave behind a vaccine scar. The proper use of vaccine and isolation is the best way to stop the spread of smallpox. This represented "Target Zero", the objective of the campaign. Find out who should get smallpox vaccine. Smallpox is an infection of the variola virus. government. This consisted of transferring to healthy people small amounts of material from smallpox sores, resulting in milder forms of illness and much lower mortality than natural infection. WHO poster commemorating the eradication of smallpox in October 1979, which was officially endorsed by the 33rd World Health Assembly on May 8, 1980. The chief reason for the end of smallpox vaccination was fairly obvious. [15]:292 Vaccination results in a skin lesion that fills with pus and eventually crusts over. Edward Jenner referred to cowpox as variolae vaccinae (smallpox of the cow). Also included is an antibody which specifically binds to the proteins and nucleic acid encoding the same, as well as methods of preventing and treating a poxvirus infection using the afore . Key components of the worldwide smallpox eradication effort included universal childhood immunization programmes in some countries, mass vaccination in others, and targeted surveillance-containment strategies during the end-game. Submission #144762", "FDA approves first live, non-replicating vaccine to prevent smallpox and monkeypox", "Phase II Trial to Assess Safety and Immunogenicity of Imvamune", "Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox", "Vaccinia (smallpox) vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2001", "Vaccines and Related Biological Products Advisory Committee Meeting", "Aventis to Donate Smallpox Vaccine To the U.S. Government's Stockpile", "Emergent BioSolutions Awarded 10-Year HHS Contract to Deliver ACAM2000, (Smallpox (Vaccinia) Vaccine, Live) Into the Strategic", "Bavarian Nordic Announces U.S. FDA Approval of Jynneos (Smallpox and Monkeypox Vaccine, Live, Non-Replicating) for Prevention of Smallpox and Monkeypox Disease in Adults", "HHS Orders 2.5 Million More Doses of JYNNEOS Vaccine For Monkeypox Preparedness", "Clinical guidance for smallpox vaccine use in a postevent vaccination program", "Smallpox eradication: destruction of variola virus stocks", "Plan national de rponse une menace de variole", "Vaiolo delle scimmie, 'abbiamo 5 milioni dosi di vaccino: pronti se servir', "Milestones in history of adult vaccination in Korea", "Edward Jenner and the history of smallpox and vaccination", "The smallpox story: life and death of an old disease", "Smallpox inoculation and the Ottoman contribution: A Brief Historiography", "Black History Month II: Why Wasn't I Taught That?